Table II.

Multivariate Cox regression analysis for the prediction of recurrence and progression in non-muscle-invasive bladder cancer.

Variables	Recurrence		Progression
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (<67 vs. ≥67 years)	1.018 (0.617–1.680)	0.943	1.075 (0.410–2.819)	0.883
Gender (male vs. female)	0.954 (0.481–1.895)	0.894	0.763 (0.170–3.433)	0.724
Grade
G1	1	-	1	-
G2	1.038 (0.527–2.044)	0.915	1.152 (0.280–4.740)	0.844
G3	1.110 (0.449–2.746)	0.821	3.240 (0.504–20.834)	0.216
Number of tumors (single vs. multiple)	1.115 (0.680–1.830)	0.666	1.108 (0.454–2.700)	0.822
Tumor size (<3 vs. ≥3 cm)	1.152 (0.709–1.873)	0.567	2.428 (0.904–6.526)	0.079
Stage (Ta vs. T1)	0.961 (0.481–1.895)	0.905	0.644 (0.174–2.390)	0.511
Intravesical therapy (No vs. Yes)	2.646 (1.397–5.014)	0.003	2.195 (0.574–8.397)	0.251
Three-gene risk signature (low vs. high)	1.519 (0.926–2.493)	0.098	4.268 (1.542–11.814)	0.005

HR, hazard ratio; CI, confidence interval.