Table II.
Dual regulation of platelets on angiogenesis.
| Dual regulation of platelets on angiogenesis | PAR-mediated | Refs. |
|---|---|---|
| Pro-angiogenic regulation of platelets by releasing angiogenic promoters: | PAR1-mediated | 50 |
| VEGF | 42,45,48, 51–58 | |
| bFGF | ||
| EGF | ||
| PDGF | ||
| MMPs | ||
| Anti-angiogenic regulation of platelets by releasing angiogenic inhibitors: | PAR4-mediated | 50 |
| Endostatin | 48,59,60 | |
| Platelet factor-4 | ||
| Thrombospondin-1 | ||
| 2-macroglobulin | ||
| Plasminogen activator inhibitor-1 | ||
| Angiostatin |
VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor; EGF, epidermal growth factor; PDGF, platelet derived growth factor; MMPs, matrix metalloproteinases.