Table 3.
Antipsychotic Discontinuation and Psychiatric Hospital Admission During 180 Days After Initiating Treatment With an Antipsychotic Medication for Early-Onset Schizophrenia
| Service | 1. Risperidone % (N = 805) | 2. Olanzapine % (N = 382) | 3. Quetiapine % (N = 260) | 4. Aripiprazole % (N = 173) | 5. Ziprasidone % (N = 125) | Statistics | ||
| χ2 | df | P | ||||||
| Antipsychotic discontinuation | ||||||||
| Any, first 180 daysa | 74.69 | 73.72 | 70.68 | 76.47 | 73.33 | 1.69 | 4 | .79 |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F a | df | P | |
| Days to discontinuationb | 56.03 (37.77) | 51.60 (33.25) | 57.70 (35.74) | 57.77 (35.82) | 51.03 (33.70) | 1.08 | 4 | .37 |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Time to discontinuation, unadjusted | 1.00 | 1.03 (0.87–1.22) | .89 (0.73–1.08) | 1.01 (0.81–1.25) | 1.03 (0.80–1.34) | |||
| Time to discontinuation, adjustedd | 1.00 | 1.01 (0.85–1.19) | .87 (.71–1.05) | 1.01 (0.81–1.25) | 0.97 (0.74–1.26) | |||
| Psychiatric hospital admission | % | % | % | % | % | χ2 | df | P |
| Any, first 180 days | 8.42 | 7.58 | 8.81 | 7.19 | 9.89 | 0.79 | 4 | .94 |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F a | df | P | |
| Days to admissionc | 37.50 (37.47) | 34.81 (43.24) | 40.59 (42.12) | 38.80 (42.78) | 35.89 (25.25) | 0.06 | 4 | .99 |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Time to admission, unadjusted | 1.00 | 0.90 (0.54–1.51) | 1.05 (0.60–1.83) | 0.86 (0.43–1.70) | 1.17 (0.57–2.38) | |||
| Time to admission, adjustedd | 1.00 | 0.96 (0.57–1.61) | 1.03 (0.59–1.81) | 0.85 (0.43–1.70) | 1.22 (0.60–2.51) | |||
Note: Data Source: 2001–2005 National Medicaid Files.
a
Denominators limited to those with days of supply of first antipsychotic medication (AP) >0 and ≤45 and at least 2 claims with first listed ICD-9 code for schizophrenia during 360 days around date of AP initiation. HR denotes hazards ratio.
b
Denominators limited to patients who have discontinued antipsychotic medications.
c
Denominators limited to patients with a psychiatric hospital admission.