Table 2.
SPM Results. The Z is given uncorrected, the P is corrected for multiple testing according to the false discovery rate method for the voxel with the highest value (x, y, z stands for Talairach coordinates). Cluster volume is given in cubic centimetre, ie, cc (equivalent to millilitre).
Brain region | Brodmann’s area (BA) | P (FDR-cor) | Z score | x, y, z coordinates | Cluster volume (cc) | ||
x | y | z | |||||
Controls vs patients contrast | |||||||
Thalamus (R/L) | <2 × 10−16 | 6.28 | −11 | −31 | 4 | 17.8 | |
Medial temporal gyrus/medial and superior occipital gyrus/inferior parietal lobule (L) | 39/19 | <2 × 10−16 | 6.14 | −41 | −82 | 23 | 45 |
Medial temporal gyrus/medial and superior occipital gyrus/inferior parietal lobule (R) | 19 | <2 × 10−16 | 5.87 | 37 | −78 | 39 | 42 |
Inferior frontal gyrus (R) | 45 | <2 × 10−16 | 5.14 | 49 | 16 | 5 | 10.8 |
Calloso-marginal sulcus (L) | 10 | <2 × 10−16 | 4.84 | −10 | 51 | 19 | 2.4 |
Medial frontal gyrus (R) | 10 | <2 × 10−16 | 4.83 | 10 | 48 | −7 | 1.3 |
Fusiform gyrus (L) | 19 | <2 × 10−16 | 4.8 | −23 | −59 | −25 | 5.7 |
Precentral sulcus (L) | 6 | <2 × 10−16 | 4.54 | −34 | −12 | 62 | 1.6 |
Superior frontal gyrus (R) | 6 | <2 × 10−16 | 4.42 | 16 | −6 | 69 | 2.4 |
Fusiform gyrus (R) | 37 | 0.001 | 4.42 | 44 | −59 | −42 | 6.5 |
Inferior frontal gyrus/superior temporal pole (L) | 47/38 | 0.001 | 4.28 | −38 | 21 | −17 | 2.8 |
Calloso-marginal sulcus (R) | 9 | 0.001 | 4.19 | 8 | 52 | 28 | 3.7 |
Group × Age interaction contrast | |||||||
Parieto-occipital sulcus/cuneus (R) | 19 | 0.7 | 3.02 | 35 | −81 | 37 | 1.8 |
Parieto-occipital sulcus/cuneus (L) | 19 | 0.7 | 2.5 | −33 | −89 | 35 | 2 |
Group × Center interaction contrast | |||||||
Middle occipital gyrus/Parieto-occipital sulcus (R) | 19 | 0.4 | 4.1 | 46 | −80 | 4 | 6.2 |
Middle occipital gyrus (L) | 19 | 0.4 | 3.7 | −35 | −89 | 8 | 4.5 |
Note: R, right; L, left.