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. 2011 Sep 6;2(6):1065–1071. doi: 10.3892/ol.2011.415

Figure 1.

Figure 1

(A) Expression of stem cell markers in UC-CRC and inflamed colonic epithelium. Expression of PROM, POU5F1 and NANOG were significantly lower in UC-CRC than in inflamed colonic epithelium (P=0.0335 for PROM, P=0.0011 for POU5F1 and P=0.006 for NANOG). Box and whisker plots were used to show the distribution of mRNA levels of PROM, POU5F1 and NANOG for each group. The horizontal line in the box represents the 50th (median) and the upper and lower lines of the box represent the 75th and 25th quartiles, respectively. The whiskers indicate the range of the measurements. (B) Levels of stem cell markers in sporadic CRC and adjacent normal epithelium. PROM, POU5F1 and NANOG were significantly higher in sporadic CRC than in adjacent normal colonic epithelium (P=0.0001 for PROM, P=0.0423 for POU5F1 and P=0.0416 for NANOG). (C) Comparison of PROM, POU5F1 and NANOG in UC-CRC and sporadic CRC. POU5F1 and NANOG levels were significantly lower in colitis-associated CRC than in sporadic CRC (P=0.0097 for POU5F1, and P=0.0189 for NANOG). No significant difference was observed in PROM between colitis-associated and sporadic CRC.