Figure 3.
Epigenetically reprogrammed EPCs have increased acH3K9 associated with cardiac-specific promoters. (a) ChIP assay at CMC-associated gene promoters and 2 regulatory regions of Oct4 CP=core promoter, RP=regulatory promoter. Values represent percent of total input. * p<0.05 (b) Pyro-sequencing of the Nkx2.5 promoter from isolated and bisulfite converted genomic DNA from SVECs with either no drug, VPA/5′Aza or BIX-01294. Converted NIH-3T3 gDNA was used as a positive control.