Table 2.

Continuation ratio model for the time to first inability to test fitted to the SIB and BPT scores

	SIB		BPT
Variable	Est. odds ratio (95% CI)	p-value	Est. odds ratio (95% CI)	p-value
Baseline age (years)	1.12 (0.98, 1.29)	0.104	1.10 (0.96, 1.26)	0.154
Female	0.52 (0.14, 1.89)	0.321	0.52 (0.15, 1.79)	0.297
APOE4	1.50 (0.36, 6.30)	0.582	0.50 (0.11, 2.29)	0.373
Pre-morbid cognitive impairment: Severe or profound	0.56 (0.00, 502.66)	0.869	0.62 (0.00, 373.09)	0.882
Treatment group (antioxidant vs. placebo)	4.61 (1.22, 17.35)	0.024	2.70 (0.68, 10.75)	0.160
Baseline DMR SC score (pre-morbid CI: not severe or profound)	1.10 (1.00, 1.21)	0.041	1.04 (0.95, 1.14)	0.358
Baseline DMR SC score (pre-morbid CI: severe or profound)	1.08 (0.88, 1.32)	0.477	1.05 (0.87, 1.27)	0.621
Years since dementia onset at baseline	1.42 (0.94, 2.15)	0.099	1.36 (0.91, 2.03)	0.138
Seizure status (yes vs. no)	11.02 (1.59, 76.27)	0.015	9.02 (1.90, 42.85)	0.006

Point estimates are reported on the odds ratio scale of the conditional probability of inability to test at a particular time given the subject is at risk at that particular time. Regression estimates are adjusted for all variable listed in the table. CI-Cognitive impairment.