FIGURE 8.

Glucose and fatty acid oxidation shift in murine and human sepsis. Both murine and human sepsis analyses were performed during the adaptation stage (mice at 24 h after CLP and humans at least 24 h after sepsis onset). A, mitochondrial glucose oxidation is decreased in sepsis murine splenocytes. B, mitochondrial palmitic acid oxidation is increased in sepsis murine splenocytes. C, mitochondrial fatty acid regulators are modified in sepsis murine splenocytes. D, mitochondrial glucose oxidation is decreased in human sepsis leukocytes. E, mitochondrial palmitic acid oxidation is increased in human sepsis leukocytes. F, mitochondrial fatty acid regulators are modified in human sepsis leukocytes. Data are mean values ± S.E. N, normal; P, patients.