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. 2012 May 30;287(31):25869–25880. doi: 10.1074/jbc.M112.375204

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Regulation of histone H3 acetylation by manipulating HAT or HDAC. a, incubation of rMC-1 cells in 30 mm glucose led to a significant increase in histone H3 acetylation, and this was inhibited by a HAT inhibitor (garcinol (Gar)), by HDAC activators (theophylline (Theo) and resveratrol (Resv)), and by minocycline (Mino). b, likewise, the increased acetylation of histone H3 in high glucose was inhibited by siRNA against p300 but not by an inactive control. Acetylation of histones was increased above normal in cells grown with the HDAC inhibitor, SAHA. The data in both figures summarize results from six dishes and Western blot data from three representative dishes.