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. 2012 Jun 12;287(31):25954–25963. doi: 10.1074/jbc.M111.313809

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Proposed model for the aberrant actin cytoskeleton organization in the epidermis of psoriatic skin. p38 MAPK and ERK activate MK5. The expression of hTid-1_S inhibits the kinase activity of MK5 which phosphorylates HSP27 and attenuates F-actin polymerization in keratinocytes of normal skin. However, the loss of hTid-1 expression in the hyperthickened epidermis of psoriatic skin fails to inhibit MK5 activity, leading to the increased HSP27 phosphorylation, aberrant actin cytoskeleton organization, and hyperproliferation of keratinocytes.