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Quantification of the interaction between RAR-RXR and different RAR binding element oligonucleotides by ITC. A, representative ITC titrations of RAR/RXR to the indicated DR/IR elements are shown. RAR-RXR binds DR5, DR2, DR0, and IR0 with a stoichiometry of 1 DNA per heterodimer. B, thermodynamic parameters (dissociation constant (Kd), enthalpy (ΔH), and entropy (−TΔS)) of DNA binding to RAR-RXR was determined by ITC.
