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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Cancer Cell. 2012 Jul 10;22(1):5–6. doi: 10.1016/j.ccr.2012.06.006

Figure 1. The Fanconi Anemia pathway and BRCA2 cooperate to promote the stability of stalled replication forks.

Figure 1

(A) FA proteins and BRCA2 protect stalled replication forks against degradation by stabilizing RAD51 filaments. (B) In the absence of the FA/BRCA pathway, the MRE11 nuclease degrades stalled replication forks, promoting genomic instability. (C) Fork protection in FA/BRCA pathway mutants can be rescued by stabilizing RAD51 filaments. RAD51 is represented by red dots.