Table 1.

Number of DEGs and significantly modified pathways between Npc1^−/− and control mice at each age

Age	Number of genes (P-value ≤ 0.05 and |FC|≥1.3)a	Number of significant pathway maps (FDR step-up value ≤0.05 in GeneGo)b
1 week	1319 (753; 57%)	9 (59%)
3 weeks	2618 (1461; 56%)	10 (69%)
5 weeks	2487 (1626; 65%)	71 (90%)
7 weeks	3507 (2162; 62%)	117 (87%)
9 weeks	5783 (3145; 54%)	157 (77%)
11 weeks	6035 (2973; 49%)	119 (59%)
Total	11 290	222

^aNumber and percentage of upregulated genes are given in parentheses.

^bPercentage of pathways containing >75% of upregulated genes is given in parentheses.