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Inhibition of Wnt signaling in pancreas tumor induces mucininous differentiation and decreased nuclear β-catenin and cellular proliferation. Shown is staining of sections of pancreatic tumor PN4 with Alcian blue to highlight mucin (A and B), and with anti–β-catenin (C and D) and with anti-Ki-67 to indicate proliferating cells (E and F). Sections are from tumors following treatment (41 d) with control antibody (A, C, and E) or OMP-18R5 (B, D, and F).
