Fig. 4.

Keratinocyte-specific Bmal1 deletion has no effect on hair cycle progression but obliterates time-of-day–dependent variation of S-phase in the interfollicular epidermis and upper follicles. (A) Quantification of hair follicle stages at P24 in Bmal1^−/−, Bmal1^fl/+;K14Cre, and Bmal1^fl/fl;K14Cre mice. (B) Quantification of BrdU-positive cells in the interfollicular epidermis of P24 Bmal1^fl/+;K14Cre and Bmal1^fl/fl;K14Cre mice at the indicated times. (C) Quantification of BrdU-positive cells in the upper hair follicles of P24 Bmal1^fl/+;K14Cre and Bmal1^fl/fl;K14Cre mice at the indicated times. The error bars represent SEM for three or four biological replicates. P values were determined by Student’s t test.