Figure 5.

POD change significance maps of the progressing eye (in Figs. 2 and 3) illustrating a hypothetical example of changing the baseline (a–c). After a change in baseline, the POD framework generates change significance maps from the next follow-up onwards. The POD framework also can use all available exams until the new baseline to improve specificity. By using both exams from 2001 and 2002 as baseline, the POD framework results in a decrease in the positive rate (c), indicating that some of the changes observed when using the 2002 exam only as baseline (b) could be explained by the inter-exam variability between 2001 and 2002.