Table 2.  .

Diagnostic Accuracy of the POD Framework Based on Localized Retinal Changes Using the Three Type I Error Control Strategies

Method	Type I Error Controlled	Type I Error Control Approach	Progression Criteria	Diagnostic Accuracy (Reduction in Retinal Height from Baseline ≥0 μm)
				Progressors: Sensitivity, N = 36 Eyes (95% CI)	Longitudinal Normals: Specificity, N = 21 Eyes (95% CI)	Non-progressors: Specificity, N = 210 Eyes (95% CI)
POD with Bonferroni Correction	FWER	Bonferroni Correction: FWER ≤5%	At least 1 follow-up with OPR >0%	100% (99–100%)	0% (0–0%)	0% (0–2%)
POD with k-FWER control	k-FWER	Lehmann & Romano 2005: k-FWER ≤1%	At least 1 follow-up with OPR >5%	78% (63–93%)	86% (68–100%)	43% (36–50%)
POD with FDR control	FDR	Benjamini & Hochberg 1995: FDR ≤5%	At least 1 follow-up with OPR >5%	78% (63–93%)	86% (68–100%)	43% (36–50%)