Table 4.  .

Diagnostic Accuracy of the HRT TCA Using the Liberal, Moderate, and Conservative Criteria of Progression Defined Using the Retinal Locations with Significant Reduction in Retinal Height (i.e., red superpixel) Repeatable in 3 of 3, or 3 of 4 Successive Follow-ups

TCA Criterion (Chauhan et al.4)	Diagnostic Accuracy
	Progressors: Sensitivity, N = 36 Eyes (95% CI)	Longitudinal Normals: Specificity, N = 21 Eyes (95% CI)	Non-progressors: Specificity, N = 210 Eyes (95% CI)
Liberal criterion	86% (73–99%)	62% (39–85%)	21% (16–27%)
Moderate criterion	53% (35–70%)	100% (98–100%)	70% (64–77%)
Conservative criterion	17% (3–30%)	100% (98–100%)	94% (91–98%)

Liberal criterion, size of the largest cluster of red superpixels in disk ≥0.5% of disk area and retinal height decrease from baseline ≥20 μm; moderate criterion, size of the largest cluster of red superpixels in disk ≥1% of disk area and retinal height decrease from baseline ≥ 50 μm; and conservative criterion, size of the largest cluster of red superpixels in disk ≥2% of disk area, and retinal height decrease from baseline ≥100 μm.