Table 1.

Plasma Proteins with Significantly Elevated Levels in Tumor-Bearing Mice from the Lung Adenocarcinoma Models

Gene	Lung Mouse Models				Cell Lines
	EGFR	Kras	Urethane	SCLC	Total Cell Extract	Cell Surface	Media
Sftpb	4.83	3.41	1.99	—	0	1	2
Morc3	*	10	10	—	0	0	0
Fgfr2	9.8	*	—	—	2	1	0
Adam10	7.85	1.5	—	—	3	12	11
Man2b2	4.22	1.46	—	—	1	0	7
Tfpi2	10	*	—	—	5	5	8
Son	*	10	—	—	1	1	6
Eif2ak3	*	9.03	—	—	1	0	0
Hamp2	*	3.07	—	—	NA	NA	NA
Ncan	*	1.45	—	—	2	1	0
Sftpd	10	—	10	—	2	1	3
Mocs1	1.71	—	1.3	—	0	0	1
Nup188	—	*	10	—	0	1	1
Igsf4a	3.55	1.48	1.55	3.32	0	0	0
Ppbp	1.63	1.7	5.12	1.39	0	0	0
Prtg	10	10	—	10	0	0	0

Numbers for each mouse model indicate the case:control ratio based on the identification of peptides containing cysteine residues labeled with heavy and light acrylamide isotopes. Dashes (—) indicate that the quantitative ratio was not calculated. Asterisks (*) indicate proteins that were only identified in plasma from tumor-bearing mice. Thirteen proteins were significantly elevated (case:control ratio > 1.25; p < 0.05, t test) in mice bearing lung adenocarcinoma tumors or only identified in tumor bearing mice from at least two of the three lung adenocarcinoma models, but not in any other mouse models. Three proteins (Igsf4a, Ppbp, and Prtg) were increased in mice bearing adenocarcinomas and SCLC tumors but not in the other models. The numbers in the columns for cell lines indicate the number of cell lines in which a protein was identified in any of the whole cell extract, the cell surface, or the conditioned media. The entire dataset is available in Table S4 and Table S5.