Table 1.
Demographic and clinical-pathologic comparisons of patients with HCC associated with underlying HBV vs. those with HCV-associated HCC
| All (n = 127) | HBV (n = 89) | HCV (n = 38) | P value † | ||
|---|---|---|---|---|---|
|
Gender | |||||
| |
Male |
115 (90%) |
85 (95%) |
30 (79%) |
p = 0.007 |
| |
Female |
12 (10%) |
4 (5%) |
8 (21%) |
|
|
Race | |||||
| |
Asian |
82 (65%) |
80 (90%) |
2 (5%) |
p < 0.001 |
| |
Non-Asian |
45 (35%) |
9 (10%) |
36 (95%) |
|
|
Age | |||||
| |
Median |
53 |
50 |
58 |
NS |
| |
Range |
21-79 |
21-75 |
47-79 |
|
| |
Distribution |
|
|
|
|
| |
21-30 |
5 (4%) |
5 (6%) |
0 (0%) |
|
| |
31-40 |
18 (14%) |
18 (20%) |
0 (0%) |
p < 0.001 ‡ |
| |
41-50 |
23 (18%) |
21 (24%) |
2 (5%) |
|
| |
51-60 |
50 (39%) |
28 (31%) |
22 (58%) |
|
| |
>60 |
31 (24%) |
17 (19%) |
14 (37%) |
|
|
Comorbidities | |||||
| |
Mean ± S.D |
1.6 ± 1.6 |
1.0 ± 1.1 |
2.9 ± 1.5 |
p < 0.001 |
|
Alcohol abuse | |||||
| |
|
18 (15%) |
6 (7%) |
12 (32%) |
p < 0.001 |
|
HIV coinfection | |||||
| |
|
8 (6%) |
1 (1%) |
7 (13%) |
p < 0.001 |
|
Cirrhosis state in the non-neoplastic liver (n = 119) | |||||
| |
Non-cirrhosis |
34 (29%) |
34 (40%) |
0 (0%) |
p < 0.001 |
| |
Cirrhosis |
85 (71%) |
50 (60%) |
35 (100%) |
|
|
AFP levels (n = 122) | |||||
| |
Median |
137 |
1000 |
37 |
p = 0.002 |
| |
Range |
3-871,485 |
3-871,485 |
4-59,739 |
|
| |
Distribution |
|
|
|
|
| |
≤ 9 |
20 (16%) |
13 (15%) |
7 (19%) |
NS * |
| |
9-20 |
10 (8%) |
7 (8%) |
3 (8%) |
NS * |
| |
20-100 |
27 (22%) |
10 (12%) |
17 (46%) |
p < 0.001 * |
| |
100-1,000 |
15 (12%) |
11 (13%) |
4 (11%) |
p < 0.001 * |
| |
1,000-10,000 |
27 (22%) |
23 (27%) |
4 (11%) |
p = 0.01 * |
| >10,000 | 23 (19%) | 21 (25%) | 2 (5%) | ||
† P values were obtained by Fisher’s exact test, two-tailed t test or non-parametric Mann–Whitney U test.
‡ p < 0.001 when comparing HCC developing under age 40 in HBV vs. HCV.
* p values obtained when comparing distribution with AFP cut-off at 9, 20, 100, 1,000, or 10,000 in HBV vs. HCV.
NS: not significant.