Table 3. Association analysis of rs28461391, rs3859501, rs12983273 on the pri-miRNA region of miRNAs-371-372-373 with risk of liver disease in HBV infected patients (n = 1,439).

rs#	Minor allele frequency		Codominant		Dominant		Recessive
	Case	Control	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
HCC occurrence
HCC occurrence (n = 417) vs. non-occurrence (n = 618) among chronic HBV carriers
rs28461391	0.122	0.132	0.98(0.74–1.31)	0.91	0.93(0.67–1.29)	0.66	1.61(0.60–4.26)	0.34
rs3859501	0.373	0.414	0.75(0.61–0.92)	0.005	0.71(0.53–0.94)	0.02	0.66(0.45–0.96)	0.03
rs12983273	0.058	0.044	1.22(0.78–1.92)	0.39	1.22(0.78–1.92)	0.39	.	.
ht1 (C-C-C)	0.522	0.484	1.25(1.04–1.52)	0.02	1.26(0.92–1.72)	0.15	1.47(1.07–2.01)	0.02
ht2 (C-A-C)	0.299	0.341	0.74(0.60–0.91)	0.005	0.72(0.55–0.95)	0.02	0.57(0.36–0.91)	0.02
ht3 (T-C-C)	0.104	0.100	1.09(0.80–1.49)	0.59	1.02(0.73–1.45)	0.89	2.72(0.78–9.57)	0.12
ht4 (C-A-T)	0.056	0.042	1.20(0.76–1.90)	0.43	1.20(0.76–1.90)	0.43	.	.
HCC occurrence (n = 417) vs. non-occurrence (n = 305) among liver cirrhosis patients
rs28461391	0.122	0.121	1.04(0.75–1.45)	0.82	0.99(0.68–1.43)	0.95	1.84(0.54–6.23)	0.33
rs3859501	0.373	0.444	0.69(0.55–0.86)	0.001	0.60(0.43–0.84)	0.003	0.63(0.41–0.95)	0.03
rs12983273	0.058	0.043	1.27(0.75–2.14)	0.37	1.27(0.75–2.14)	0.37	.	.
ht1 (C-C-C)	0.522	0.466	1.33(1.07–1.65)	0.01	1.30(0.91–1.84)	0.15	1.67(1.16–2.42)	0.006
ht2 (C-A-C)	0.299	0.370	0.67(0.53–0.85)	0.0009	0.65(0.47–0.89)	0.007	0.49(0.30–0.81)	0.005
ht3 (T-C-C)	0.104	0.090	1.18(0.82–1.70)	0.38	1.13(0.75–1.69)	0.56	2.82(0.58–13.73)	0.20
ht4 (C-A-T)	0.056	0.043	1.24(0.73–2.10)	0.43	1.24(0.73–2.10)	0.43	.	.
HBV clearance
Chronic HBV carriers (n = 1,035) vs. spontaneously recovered (n = 404)
rs28461391	0.128	0.146	0.86(0.68–1.08)	0.19	0.88(0.67–1.15)	0.34	0.55(0.26–1.15)	0.11
rs3859501	0.398	0.398	1.01(0.85–1.19)	0.95	0.96(0.75–1.22)	0.73	1.10(0.79–1.52)	0.57
rs12983273	0.049	0.057	0.88(0.61–1.27)	0.49	0.90(0.62–1.31)	0.58	.	.
ht1 (C-C-C)	0.499	0.481	1.07(0.91–1.26)	0.44	0.99(0.76–1.28)	0.92	1.22(0.92–1.60)	0.16
ht2 (C-A-C)	0.324	0.316	1.04(0.87–1.24)	0.66	1.02(0.81–1.29)	0.85	1.14(0.77–1.70)	0.52
ht3 (T-C-C)	0.102	0.121	0.82(0.64–1.06)	0.13	0.84(0.63–1.11)	0.23	0.50(0.21–1.21)	0.13
ht4 (C-A-T)	0.048	0.057	0.86(0.59–1.24)	0.41	0.88(0.60–1.28)	0.49	.	.

Minor allele frequencies and P values for logistic analyses of three alternative models (co-dominant, dominant, and recessive models) are shown.

Abbreviations: HCC, hepatocellular carcinoma; HBV, hepatitis B virus; OR, odds ratio; CI, confidence interval.