Table 2. Diagnostic performances of LSM, FT and ELF and their suggested optimal cutoff values.

Fibrosis stage	Method	AUROC (95% CI)	Cutoffs	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
	ELF	0.901 (0.849–0.953)	8.50	86.0	85.7	93.7	71.2
F≥2	LSM	0.937 (0.903–0.971)	8.0 kPa	77.7	95.9	97.9	63.5
	FT	0.896 (0.850–0.942)	0.31	75.2	97.9	98.9	61.5
	ELF	0.860 (0.805–0.915)	9.40	83.5	77.7	78.9	82.5
F≥3	LSM *	0.956 (0.929–0.983)	10.1 kPa	90.6	96.5	96.2	91.1
	FT *	0.921 (0.877–0.964)	0.51	85.8	97.7	97.3	87.4
	ELF	0.862 (0.809–0915)	10.10	70.2	78.9	55.9	87.4
F = 4	LSM *	0.963 (0.937–0.989)	14.0 kPa	87.2	91.1	78.8	94.9
	FT	0.881 (0.828–0.935)	0.67	78.7	78.8	68.5	91.4

Abbreviations: ELF, enhanced liver fibrosis; LSM, liver stiffness measurement; FT, FibroTest; AUROC, area under the receiver operating characteristics curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.

^*p<0.05 compared to AUROC of ELF using Hanley and McNeil test.