Figure 4. Cd-mediated cellular responses in T. gammatolerans.

Transcriptional response induced at 120 min when T. gammatolerans cells are exposed to 1mM Cd. (ADP-ACS) ADP-forming acetyl-CoA synthetase; (AMP-ACS) AMP-forming acetyl-CoA synthetase; (CoA) coenzyme A; (DMT) drug/metabolite transporter; (F1,6BP) fructose 1,6-bisphosphate; (F₄₂₀ HG) F₄₂₀ reducing dependent hydrogenase; (Fdred) reduced ferredoxin; (Fdox) oxidized ferredoxin; (FDH) formate dehydrogenase; (FH) fumarate hydratase; (FRD) fumarate reductase; (F6P) fructose 6 phosphate; (G6P) glucose 6 phosphate; (GAP) glyceraldehyde 3 phosphate; (GAPDH) glyceraldehyde 3 phosphate deshydrogenase; (GAPOR) glyceraldehyde 3 phosphate ferredoxin oxydoreductase; (KGOR) ketoglutarate:ferredoxin oxydoreductase; (KPHMT) ketopentoate hydroxymethyltransferase; (MATE) multi antimicrobial extrusion protein; (Mbc) membrane-bound complexe; (Mbh) membrane-bound hydrogenase; (MDH) malate deshydrogenase; (MFS) major facilitator superfamily transporter; (Mhy2) formate hydrogenlyase II; (MMM) methylmalonyl-CoA mutase; (OAD) oxaloacetate decarboxylase; (2PG) 2 phosphoglycerate; (3PG) 3 phosphoglycerate; (PCK) phosphoenolpyruvate carboxykinase; (PEP) phosphoenolpyruvate; (PGK) phosphoglycerate kinase; (PGP) 2,3 bisphosphoglycerate; (POR) pyruvate:ferredoxin oxidoreductase; (PPS) phosphoenolpyruvate synthase; (PYC) pyruvate kinase; (SCS) succinyl-CoA synthetase. *tg0041 and tg0061 genes are also induced at 0.1 mM Cd. ORF item is indicated under brackets. Red: upregulated genes (FC ≥2 and p-Value ≤ 0.01); green: downregulated genes (FC ≤ −2 and p-Value ≤ 0.01).