Table 2. Serum TNF Responses to LPS Challenge.* .
| WT (Il10 +/+) | Heterozygous(Il10 +/−) | Knock-Out (Il10 −/−) | |
| WT (Tnf +/+) | 9165±1671 (n = 12) | Not Done | 17,586±3206 (n = 9)a |
| Heterozygous(Tnf +/−) | 1659±145 (n = 5) | 2357±323 (n = 7) | 5,417±316 (n = 5)b |
| Knockout (Tnf −/−) | 0 (n = 5) | 0 (n = 7) | 0 (n = 5) |
*
Data shown are mean ± SEM, in pg/ml as measured by enzyme immunoassay. Mice heterozygous for IL-10 alone were not studied since they were not generated in large numbers by our chosen breeding scheme.
a
p<0.05 vs. WT; ANOVA with Tukey’s post-test.
b
p<0.05 vs. Il10 −/−; ANOVA with Tukey’s post-test.