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. 2012 Jul 27;7(7):e42357. doi: 10.1371/journal.pone.0042357

Figure 1. Effect of age on tissue lipid peroxidation in (A) males (B) females.

Figure 1

(A) Lipid peroxidation increases with age in male subjects. MDA levels in human tissue increased significantly with age in males aged between 0–77 years (Line a; p = 0.0003; n = 27). Line b shows post-pubescent (males only) data (p = 0.0044; n = 19). Spearman's correlation coefficient for the non-normally distributed population was r = 0.643 and r = 0.623 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Changes in lipid peroxidation with age in female subjects. The apparent increase in MDA levels in post-pubescent females (36–76 years) is not statistically significant (p = 0.3734; n = 22). Spearman's Correlation coefficient for a non-normally distributed population was 0.200. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.