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. 2012 Jul 27;7(7):e42357. doi: 10.1371/journal.pone.0042357

Figure 2. Correlation between Phosphorylation of H2AX at Ser139 and age in both (A) Males (B) Females.

Figure 2

(A) Phosphorylated-H2AX as a marker for DNA damage in male subjects show a significant correlation with age. Line a represents the correlation for subjects aged between 0–77 years (p = 0.0095; n = 27). Line b shows post-pubescent data (males only) (p = 0.0286; n = 19). Pearson's Correlation coefficient for normally distributed data was r = 0.490 and r = 0.502 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Phosphorylated-H2AX as a marker for DNA damage in post-pubescent female subjects shows a significant positive correlation with age (36–76 years) (p = 0.003; n = 22). Pearson's Correlation coefficient for a normally distributed population was r = 0.600. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.