Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jul 27;7(7):e41033. doi: 10.1371/journal.pone.0041033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Forgione, Tropepe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Differentiated midbrain cultures were treated with 330 nM TSA, 50 mM SB or 50 mM VPA respectively for 48 hours and gene expression was analyzed using Agilent whole mouse genome expression microarray chips. Genes with a p-value of <0.02 were considered differentially expressed (DEGs) and subjected to Venn analysis. (A) A total of 895 genes are up-regulated by HDACi treatment. A subset of 127 of these genes are up-regulated by all three drug. (B) A total of 1360 genes are down-regulated as a result of HDACi treatment, with a subset of 373 genes being down-regulated by all three drugs. Numbers represent the total number of modulated genes in that experimental condition.