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. 2012 Jul 27;7(7):e41116. doi: 10.1371/journal.pone.0041116

Figure 7. Rbpj inactivation reverses the impaired vascular growth of Fbxw7 mutant mice.

Figure 7

Whole-mount Isolectin B4 staining of the retinal vasculature in P6 control, Fbxw7 iECKO/Rbpj +/iECKO (Fbxw7 homozygous & Rbpj heterozygous EC-specific KO), Fbxw7 iECKO/Rbpj iECKO (Fbxw7 & Rbpj EC-specific double KO), and Fbxw7 +/iECKO/Rbpj iECKO (Fbxw7 heterozygous & Rbpj homozygous EC-specific KO), mice, as indicated. Inactivation of both Rbpj alleles enhanced EC proliferation and sprouting, and restored retinal angiogenesis in the Fbxw7 mutant background. Scale bar represents 200 µm. Three independent experiments were performed with similar results.