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. 2012 Jul 27;7(7):e41089. doi: 10.1371/journal.pone.0041089

Figure 2. Pax7-cre/reporter mice for lineage tracing neural crest derivatives.

Figure 2

A,B,D) Equivalent Pax7 expression domains are seen in the frontonasal region (arrows) and neural tube (arrowheads) of E11.5 mouse embryos from different Pax7 transgenic lines: A,D) Pax7 LacZ (LacZ stain) and B) Pax7-cre/ROSA YFP (endogenous YFP expression). C) A littermate control, lacking YFP expression. E,F) E9.5 Pax7-cre/ROSA LacZ embryos show LacZ stain in neural crest regions, such as the frontonasal region (arrow) and cells leading to the pharyngeal arches (arrowheads). Box in (E) magnified in (F). G–I) In E11.5 Pax7-cre/ROSA YFP embryos, co-expression of Pax7 (red) and YFP reporter (green) can be detected in G) the neural tube (NT), H,I) olfactory epithelium (OE) and frontonasal mesenchyme (FNM; arrows). Inset highlights boxed region. Scale bars in G–I 100 um.

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