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. 2012 Jul 27;7(7):e41089. doi: 10.1371/journal.pone.0041089

Figure 5. Pax7 contributions to trunk neural crest.

Figure 5

A–C) At E11.5 and D–H) E15.5 in Pax7-cre/ROSA reporter mice, Pax7 descendants (YFP+ or LacZ+, respectively) are detected in the neural tube (NT), including commissural axons (asterisk), dermomyotome (DM) and dorsal root ganglia (DRG). A–C) Only a subset of the total DRG neurons (TUJ1+, red) arise through the Pax7 lineage (YFP+, arrow). Neurons throughout the DRGs express E) P75 (red) and F,H) peripherin (red), including D–H) LacZ+ Pax7 descendants (arrows). In E,H), the LacZ signal (green) was pseudocolored in Photoshop. I,J) Within the physiological umbilical hernia, subsets of Pax7 descendants (LacZ+) are detected in the lining of the midgut (white arrow) and presumptive enteric neurons (black arrow, J), K,L) sympathetic tissue (arrows) and adrenal gland (all E15.5). Boxes show magnified region in adjacent panel. DA-dorsal aorta. Scale bars in A,I,K -500 um; B,C,F,J,K magnified region −200 um.

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