Table 4. Downregulated functions in CC_MII compared to CC_GV.

Function	p-value
vitamin binding	0.0021
tRNA processing	0.0036
positive regulation of development process	0.0068
4-aminobutyrate transaminase activity	0.0071
N-acetyl-gamma-glutamyl-phosphate reductase activity	0.0071
phosphoglucomutase activity	0.0071
pseudouridylate synthase activity	0.0071
vitamin D binding	0.0071
bleomycin hydrolase activity	0.0071
queuine tRNA-ribosyltransferase activity	0.0071
queuosine biosynthesisprocess	0.0071
7-methylguanosine metabolism process	0.0071
nucleoside biosynthesis process	0.0071
response to tropane	0.0071
tyrosyl-DNA phosphodiesterase activity	0.0071
stem cell maintenance	0.0071
calcium channel inhibitor activity	0.0071
pyridoxal phosphate binding	0.0071
troponin T binding	0.0071
4-aminobutyrate transaminase complex	0.0071
succinate-semialdehyde dehydrogenase binding	0.0071
response to cocaine	0.0071
purine nucleoside biosynthesis process	0.0071
ribonucleoside biosynthesis process	0.0071
MCM complex	0.0071
positive regulation of axon extension	0.0071
guanosine biosynthetic process	0.0071
queuosine metabolic process	0.0071
7-methylguanosine biosynthesis process	0.0071
purine ribonucleoside biosynthesis process	0.0071
behavioral response to cocaine	0.0071
stem cell differentiation	0.0071
stem cell development	0.0071
cofactor binding	0.0078
induction of apoptosis	0.0091
induction of programmed cell death	0.0093
tRNA metabolism process	0.0094

CC_MII, cumulus cells from mature oocyte;

CC_GV, cumulus cells from oocyte at germinal vesicle stage.