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. 2012 Jul 27;7(7):e41486. doi: 10.1371/journal.pone.0041486

Figure 1. Schematic diagram of the FMDV genome and plasmids used in this study.

Figure 1

The FMDV full-length genome cDNAs in these plasmids derived from the infectious cDNA clone, pOFS, were preceded by a synthetic T7 RNA polymerase promoter. The mutant plasmid pOSF-FLAG was produced by substituting native amino acid of the 85–92 region of the 3A protein for FLAG tag sequence and pOFS-HSV was produced by substituting native amino acids of the 133–143 region of the 3A protein for HSV tag sequence. Amino acid sequences of the tag are underlined. UTR: non-coding region. (-) indicates a naturally absent sequence.