Figure 7. Dynamics of the ECM-protease regulation cascade depending on the feedback gain obtained in the simulation of Eqs. (9) and (14) for different initial conditions.

The gray area illustrates bistability. Parameter values: z₀ = p₀ = 0, z₁ = p₁ = 1, θ_z = 1,k_z = 0.15, θ_p = 1.5,k_p = 0.05, α_z = 0.001 msec⁻¹, β_z = 0.01 msec⁻¹, α_p = 0.001 msec⁻¹, β_p = 0.01 msec⁻¹, γ_P = 0.1, α₁ = 0.0001 msec⁻¹, α₂ = 0.001 msec⁻¹, I₀ = 4.5, b₀ = 6, Q₀ = 2.23, and k_I = 0.6625.