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. Author manuscript; available in PMC: 2012 Jul 28.
Published in final edited form as: Arch Pediatr Adolesc Med. 2012 Jun 1;166(6):528–535. doi: 10.1001/archpediatrics.2011.1785

Table 3.

Caregiver-Assessed CASI-4R Symptom Severity Scoresa

Characteristic ADHD-H
ADHD-I
CD
ODD
Depressionb
Anxietyc
aM P Value aM P Value aM P Value aM P Value aM P Value aM P Value
Disease History
CDC classd
 C 5.9 graphic file with name nihms370948t1.jpg .18 8.3 graphic file with name nihms370948t2.jpg .04 1.6 graphic file with name nihms370948t3.jpg .32 4.7 graphic file with name nihms370948t4.jpg .24 8.5 graphic file with name nihms370948t5.jpg .49 4.5 graphic file with name nihms370948t6.jpg .93
 N, A, B 6.8 9.8 1.9 5.3 8.0 4.4
Peak RNA VL, copies/mL
 >100 000 6.0 graphic file with name nihms370948t7.jpg .27 8.8 graphic file with name nihms370948t8.jpg .54 1.8 graphic file with name nihms370948t9.jpg .79 4.8 graphic file with name nihms370948t10.jpg .66 8.3 graphic file with name nihms370948t11.jpg .84 4.3 graphic file with name nihms370948t12.jpg .31
 0–100 000 6.8 9.3 1.7 5.1 8.2 4.6
Nadir CD4 percentage, %
 0–14 6.6 graphic file with name nihms370948t13.jpg .43 9.0 graphic file with name nihms370948t14.jpg .82 1.9 graphic file with name nihms370948t15.jpg .32 5.4 graphic file with name nihms370948t16.jpg .09 8.2 graphic file with name nihms370948t17.jpg .79 4.5 graphic file with name nihms370948t18.jpg .60
 ≥15 6.1 9.1 1.6 4.5 8.3 4.4
 Age at peak HIV RNA VLe −0.01 .90 0.09 .42 0.07 .13 0.00 .96 0.02 .82 0.02 .70
 Age at nadir CD4 percentagee 0.07 .38 −0.01 .96 0.08 .03 0.12 .10 0.10 .22 0.02 .68
Current Status
CDC class
 C 5.6 graphic file with name nihms370948t19.jpg .18 7.9 graphic file with name nihms370948t20.jpg .04 1.8 graphic file with name nihms370948t21.jpg .76 4.7 graphic file with name nihms370948t22.jpg .51 8.8 graphic file with name nihms370948t23.jpg .40 4.4 graphic file with name nihms370948t24.jpg .92
 N, A, B 6.4 9.4 1.9 5.1 8.2 4.3
Entry CD4 percentage, %
 0–24 6.4 graphic file with name nihms370948t25.jpg .25 8.9 graphic file with name nihms370948t26.jpg .49 2.2 graphic file with name nihms370948t27.jpg .04 5.3 graphic file with name nihms370948t28.jpg .19 7.7 graphic file with name nihms370948t29.jpg .02 4.5 graphic file with name nihms370948t30.jpg .48
 ≥25 5.6 8.4 1.5 4.5 9.2 4.2
Entry HIV RNA VL, copies/mL
 >10 000 5.3 graphic file with name nihms370948t31.jpg .19 7.3 graphic file with name nihms370948t32.jpg .05 1.7 graphic file with name nihms370948t33.jpg .85 4.5 graphic file with name nihms370948t34.jpg .68 9.2 graphic file with name nihms370948t35.jpg .01 4.0 graphic file with name nihms370948t36.jpg .48
 401–10 000 5.9 9.1 1.9 5.2 9.1 4.7
 0–400 6.7 9.5 1.8 5.0 7.1 4.4

Abbreviations: ADHD, attention-deficit hyperactivity disorder; ADHD-H, ADHD hyperactive-impulsive; ADHD-I, ADHD inattention; aM, adjusted mean; CASI-4R, child and adolescent symptom inventory-4R; CASI-4R, Child and Adolescent Symptom Inventory–4R; CD, conduct disorder; CDC, Centers for Disease Control and Prevention; HIV, human immunodeficiency virus; ODD, oppositional defiant disorder; VL, viral load.

a

Adjusted means and beta estimates are based on multiple regression analysis with HIV disease characteristics as predictors. Linear regression model also adjusted for age group, sex, use of efavirenz at study entry, caregiver’s biological relationship, caregiver’s educational level, life stressors during the preceding year, and caregiver’s psychiatric status.

b

Includes dysthymia and major depressive disorder.

c

Includes generalized anxiety and separation anxiety disorders.

d

Class N indicates no symptoms; A, mild symptoms; C, AIDS defined; and B, not A and not C (http://www.cdc.gov/mmwr/preview/mmwrhtml/00032890.htm).

e

Data represent regression parameter estimates.