Table 4.

Quality of Life and Cognitive, Academic, and Social Functioning Scores^a

Characteristic	QOL/Healthb			Letter-Number Sequencingb			Coding Recallb			Academic Functioningc			Social Functioningc
	aM		P Value	aM		P Value	aM		P Value	aM		P Value	aM		P Value
Disease History
CDC classd
C, severely symptomatic	7.6		.30	7.8		.29	7.9		.99	3.0		.38	2.1		.72
N, A, B	7.9			8.3			7.9			2.7			2.1
Exposure to efavirenz
Yes	7.9		.10	7.5		.01	7.7		.44	2.6		.04	1.9		.18
No	7.5			8.6			8.0			3.2			2.2
Peak RNA VL, copies/mL
>100 000	7.9		.05	7.9		.37	7.5		.04	2.8		.56	2.0		.20
0–100 000	7.5			8.2			8.2			3.0			2.2
Nadir CD4 percentage, %
0–14	7.4		<.001	8.1		.71	7.5		.04	3.1		.21	2.3		.03
≥15	8.1			8.0			8.2			2.7			1.9
Age at peak HIV RNA VLe	0.07		.03	−0.02		.79	0.03		.63	0.02		.65	−0.01		.69
Age at nadir CD4 percentagee	−0.09		<.001	−0.04		.49	−0.08		.09	0.02		.53	0.00		.99
Current Status
CDC class
C, severely symptomatic	7.6		.16	7.6		.21	7.7		.56	3.1		.27	2.1		.97
Entry CD4 percentage, %
0–24	7.7		.34	7.2		.01	7.4		.08	3.3		.07	2.2		.23
≥25	7.9			8.4			8.2			2.7			1.9
Entry HIV RNA VL, copies/mL
>10 000	8.0		.16	8.4		.13	7.9		.84	2.7		.31	1.8		.23
401–10 000	7.4			7.2			7.8			3.3			2.1
0–400	7.9			7.8			7.7			2.9			2.2

Abbreviations: aM, adjusted mean; CDC, Centers for Disease Control and Prevention; HIV, human immunodeficiency virus; QOL, quality of life; VL, viral load.

^aAdjusted means and beta estimates based on multiple regression analyses with HIV disease characteristics as predictors. Linear regression model also adjusted for age group, sex, caregiver’s biological relationship, caregiver education, life stressors during the preceding year, and caregiver’s psychiatric status.

^bHigher score indicates better functioning.

^cHigher score indicates poorer functioning.

^dClass N indicates no symptoms; A, mild symptoms; C, AIDS defined; and B, not A and not C (http://www.cdc.gov/mmwr/preview/mmwrhtml/00032890.htm).

^eData represent regression parameter estimates.