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Lens sorbitol and reduced glutathione levels from streptozotocin-induced diabetic rats fed diet with/without the aldose reductase inhibitors AL1576 or tolrestat for 10 weeks or their age-matched nondiabetic controls. Mean ± SEM; n= 4.
| Group | Sorbitol (µg/lens) |
GSH (nmol/lens) |
|---|---|---|
| Control | 5.1 ± 5.1 | 54.1 ± 1.0 |
| Diabetic | 151.9 ± 21.3 * | 19.5 ± 1.6* |
| Diabetic + AL1576 | 12.7 ± 2.6 | 51.0 ± 6.9 |
| Diabetic + Tolrestat | 19.6 ± 7.7 | 39.9 ± 3.0* |
significantly different (p ≤ 0.05) from control.
