Table 1.
Enrichment score | Process Term | Term Enrichment | Number of genes | Mean fold difference |
---|---|---|---|---|
S Strain Main effect (most significant 3000 probe sets) | DBA/B6 | |||
4.3 | Polysaccharide binding | 1.9 | 34 | 1.32 |
4.2 | Mitosis | 1.6 | 59 | 0.90 |
2.0 | Calcium-dependent phospholipid binding (Annexins) | 2.5 | 7 | 1.12 |
1.7 | Chloride ion binding | 2.1 | 11 | 0.89 |
Tissue Main Effect (1195 probe sets): | emb/plac1 | |||
7.0 | Cell adhesion | 2.0 | 61 | 1.25 |
3.8 | Polysaccharide binding | 2.5 | 19 | 1.32 |
3.5 | Ion homeostasis | 2.1 | 30 | 1.17 |
2.8 | Muscle organ development | 2.1 | 22 | 1.27 |
2.6 | Peptidase inhibitor | 2.5 | 15 | 1.31 |
2.6 | Regulation of phosphorylation | 1.7 | 33 | 1.14 |
2.5 | Regulation of cell migration | 2.2 | 14 | 1.12 |
2.1 | Response to hormone stimulus | 2.1 | 21 | 1.16 |
2.0 | Neuron development | 1.7 | 22 | 1.24 |
1.9 | Vasculature development | 1.7 | 33 | 1.20 |
1.9 | Negative regulation of transcription | 1.5 | 37 | 1.10 |
1.7 | IGF binding | 3.4 | 6 | 1.19 |
1.7 | Lung development | 2.0 | 15 | 1.19 |
1.4 | Negative regulation of apoptosis | 1.5 | 25 | 1.08 |
Ethanol main effect (283 probe sets) | EtOH/ctrls2 | |||
2.1 | Methylation | 4.2 | 7 | 0.94 |
1.9 | Chromatin organization | 2.5 | 13 | 0.91 |
1.6 | Ribosome biogenesis | 3.4 | 7 | 0.87 |
1.5 | mRNA splicing | 2.0 | 12 | 0.88 |
Strain-specific effects of ethanol | B6/DBA | |||
8.4 | mRNA splicing | 5.3 | 23 | 0.68 |
2.6 | Translation | 2.5 | 10 | 0.71 |
2.1 | Transcription | 1.5 | 36 | 0.76 |
emb/plac = embryo/placenta
EtOH/ctrls = ethanol exposure/mean of maltose dextrin and no-gavage controls