Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2012 Apr 24;36(9):1519–1529. doi: 10.1111/j.1530-0277.2012.01757.x

Table 1.

Enriched molecular functions and biological processes

Enrichment score Process Term Term Enrichment Number of genes Mean fold difference
S Strain Main effect (most significant 3000 probe sets) DBA/B6
 4.3 Polysaccharide binding 1.9 34 1.32
 4.2 Mitosis 1.6 59 0.90
 2.0 Calcium-dependent phospholipid binding (Annexins) 2.5 7 1.12
 1.7 Chloride ion binding 2.1 11 0.89
Tissue Main Effect (1195 probe sets): emb/plac1
 7.0 Cell adhesion 2.0 61 1.25
 3.8 Polysaccharide binding 2.5 19 1.32
 3.5 Ion homeostasis 2.1 30 1.17
 2.8 Muscle organ development 2.1 22 1.27
 2.6 Peptidase inhibitor 2.5 15 1.31
 2.6 Regulation of phosphorylation 1.7 33 1.14
 2.5 Regulation of cell migration 2.2 14 1.12
 2.1 Response to hormone stimulus 2.1 21 1.16
 2.0 Neuron development 1.7 22 1.24
 1.9 Vasculature development 1.7 33 1.20
 1.9 Negative regulation of transcription 1.5 37 1.10
 1.7 IGF binding 3.4 6 1.19
 1.7 Lung development 2.0 15 1.19
 1.4 Negative regulation of apoptosis 1.5 25 1.08
Ethanol main effect (283 probe sets) EtOH/ctrls2
 2.1 Methylation 4.2 7 0.94
 1.9 Chromatin organization 2.5 13 0.91
 1.6 Ribosome biogenesis 3.4 7 0.87
 1.5 mRNA splicing 2.0 12 0.88
Strain-specific effects of ethanol B6/DBA
 8.4 mRNA splicing 5.3 23 0.68
 2.6 Translation 2.5 10 0.71
 2.1 Transcription 1.5 36 0.76
1

emb/plac = embryo/placenta

2

EtOH/ctrls = ethanol exposure/mean of maltose dextrin and no-gavage controls