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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Hepatology. 2012 Oct;56(4):1499–1508. doi: 10.1002/hep.25766

Fig. 6. TCPOBOP-induced alterations of the association of ASC-2 and JMJD2a within the Cyp2B10 locus.

Fig. 6

ChIP assays were performed with anti-ASC-2 (A and B) and anti-JMJD2a (C and D) antibodies on WT and CAR KO livers. 3d(3M): 3 months post-TCPOBOP treatment on postnatal day 3. The graphs show the relative intensities of the PCR products from three mice. E. A stable cell line of HepG2 that expressed murine CAR was treated with TCPOBOP (250 nM) for 24 h. Cells were collected for ChIP assays with anti-JMJD2a antibody (left) and anti-JMJD2d antibody (right). The graphs show the relative intensities of the PCR products from three independent experiments. Motif map of CYP2B6 is indicated (upper). Abbreviation: OARE, okadaic acid response element.