Table 3.
Contrast analysis results for painful heat functional MRI activation
| Brain region | Lat. | z-stat | X (mm) | Y (mm) | Z (mm) | Vol (cm3) |
|---|---|---|---|---|---|---|
| Activations male > female | ||||||
| Insula | R | 1.8035 | 46 | 6 | 0 | 0.44 |
| Insula | R | 2.3373 | 40 | 0 | −6 | 0.464 |
| Rolandic operculum | R | 2.3857 | 48 | 4 | 10 | 0.632 |
| Rolandic operculum | L | 2.6726 | −42 | −8 | 10 | 2.24 |
| Rolandic operculum | L | 1.9971 | −46 | −30 | 22 | 0.8 |
| Putamen | R | 2.1527 | 28 | −2 | −8 | 0.656 |
| SupraMarginal | R | 2.1848 | 56 | −38 | 34 | 0.88 |
| Activations female > male | ||||||
| Superior frontal | L | 2.5885 | −18 | 16 | 46 | 0.544 |
| Precuneus | R | 3.3477 | 8 | −44 | 60 | 0.456 |
| Superior temporal | R | 3.0442 | 62 | −2 | −4 | 0.512 |
| Superior temporal | R | 2.7187 | 58 | −10 | 2 | 0.328 |
| Paracingulate | R | 2.5808 | 8 | 48 | 24 | 0.344 |
| Posterior cingulate | R | 2.6386 | 6 | −20 | 46 | 0.4 |
| Posterior cingulate | R | 2.9012 | 10 | −38 | 36 | 0.28 |
| Caudate | R | 2.7762 | 8 | 14 | 6 | 0.504 |
| Caudate | L | 2.3695 | −10 | 12 | 14 | 0.44 |
| MSN | R | 2.6017 | 12 | −36 | −40 | 0.392 |
| SpV | R | 1.912 | 0 | −40 | −52 | 2.296 |
| Cerebellum_Crus2 | L | 2.6213 | −34 | −68 | −40 | 0.224 |
| Cerebellum_Crus1 | L | 2.4506 | −44 | −72 | −32 | 1.16 |
| Deactivations male > female | ||||||
| NAc | R | −2.181 | 10 | 10 | −10 | 0.6 |
| Hypothalamus* | L | −2.5926 | −4 | 0 | −14 | 0.424 |
| Deactivations female > male | ||||||
| Hippocampus | R | −2.6758 | 30 | −14 | −18 | 0.512 |
| Amygdala | R | −2.5102 | 34 | 0 | −28 | 0.392 |
Contrast analysis of female versus male migraine patients in response to noxious heat (threshold + 1°C). *Activation in males, deactivation in females.
L = left; R = right; MSN = principle sensory trigeminal nucleus/main sensory nucleus of the trigeminal nerve; NAc = nucleus accumbens; SpV = trigeminovascular nucleus.