Table 2.
Sensitivity, Specificity, Positive and Negative predictive values of Total lymphocyte count cut-off for various CD4 groups
| TLC cut-off (cells/mm3) | Sensitivity (%) | 95% CI | Specificity (%) | 95% CI | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|---|---|
| |
1000 |
72.22 |
46.52 to 90.31 |
94.44 |
72.71 to 99.86 |
100 |
91.7 |
|
CD4 count <200 |
1200 |
72.22 |
46.52 to 90.31 |
100 |
81.47 to 100.0 |
100 |
95.7 |
|
(cells/mm3) |
1400 |
66.67 |
40.99 to 86.66 |
100 |
81.47 to 100.0 |
77.8 |
94.1 |
| |
1600 |
55.56 |
30.76 to 78.47 |
100 |
81.47 to 100.0 |
65.6 |
91.7 |
| |
1000 |
100 |
88.4 to 100 |
66.67 |
9.4 to 99.2 |
96.8 |
100 |
|
CD4 count 200–499 |
1200 |
100 |
88.4 to 101 |
67.67 |
9.4 to 99.3 |
96.7 |
66.7 |
|
(cells/mm3) |
1500 |
96.67 |
82.8 to 99.9 |
100 |
29.2 to 100 |
100 |
75.0 |
| |
1600 |
93.33 |
77.9 to 99.2 |
100 |
29.2 to 101 |
100 |
60.0 |
| |
1700 |
95.45 |
77.2 to 99.9 |
63.64 |
30.8 to 89.1 |
84.0 |
87.5 |
|
CD4 count ≥500 |
1750 |
96.45 |
77.2 to 99.10 |
72.73 |
39.0 to 94.0 |
87.5 |
88.9 |
|
(cells/mm3) |
1800 |
97.45 |
77.2 to 99.11 |
90.91 |
58.7 to 99.8 |
95.5 |
90.9 |
| 1900 | 98.45 | 77.2 to 99.12 | 100 | 71.5 to 100 | 100 | 91.7 |
TLC-Total lymphocyte count; PPV-Predictive positive value; NPV-Negative predictive value; 95% CI- 95% Confidence interval.