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. Author manuscript; available in PMC: 2012 Jul 29.
Published in final edited form as: Adv Exp Med Biol. 2009;665:143–159. doi: 10.1007/978-1-4419-1599-3_11

Fig. 2. Proposed mechanism for how FOXO influence neurons, astrocytes and neuronal progenitor cell function.

Fig. 2

In response to oxidative stress or starvation, FOXO–dependent transcription in neurons serves to trigger apoptosis by inducing gene expression of FasL, BcL-6, Bim, etc. In astrocyte, FOXO suppress cell proliferation by inducing cell cycle regulatory proteins cyclin G2, Gadd45a and p27/p21. FOXO also play a crucial role in the homeostatic maintenance of neuronal progenitor cells by coordinating quiescence, stress resistance, and/or terminal differentiation.