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. Author manuscript; available in PMC: 2013 Jul 20.
Published in final edited form as: Cell. 2012 Jul 20;150(2):264–278. doi: 10.1016/j.cell.2012.06.023

Figure 4. Background mutations in normal HSPCs accumulate as a function of age.

Figure 4

A. Number of validated SNVs per exome identified in each of 3 clones that were derived from individual hematopoietic stem/progenitor cells from 7 anonymous, healthy donors with normal blood counts. B. Clustering of mutations by clone. The Y-axis represents the analyzed clones from each donor. The X-axis represents the genes with mutations in each clone (red). Note that the two clones with ZFHX4 variants contained unique mutations (Q1660K vs. P3497A). C. Mutational spectrum in normal donor exomes (81 validated variants) vs. 24 tier 1 AML genomes (343 validated variants).