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. Author manuscript; available in PMC: 2013 Jul 20.
Published in final edited form as: Cell. 2012 Jul 20;150(2):264–278. doi: 10.1016/j.cell.2012.06.023

Figure 6. Pathway analysis of key mutations in the 24 sequenced genomes.

Figure 6

Mutations identified in Table 1 were individually curated in Pubmed for biological function. Functional categories represented by 2 or fewer mutated genes were excluded. Mutations in NPM1, DNA methylation, and cohesin genes occurred only in the M1 cases, suggesting that they may substitute for PML-RARA as initiating events, or do not productively cooperate with PML-RARA. Mutations in ubiquitin pathway genes occurred more often in M3 AML. Genes representing other functional categories were mutated in both M1 and M3 AML cases.