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. Author manuscript; available in PMC: 2013 May 25.
Published in final edited form as: Circ Res. 2012 May 25;110(11):1403–1407. doi: 10.1161/CIRCRESAHA.112.268961

Figure 2. Cardiac stem cell niche.

Figure 2

Five c-kit positive cells (green) surrounded by cardiomyocytes (myosin and desmin, red). One of the 5 c-kit-positive cells is brightly labeled by BrdU (yellow, arrow). A dimly labeled cardiomyocyte nucleus (arrowhead) is also present. The brightly BrdU-labeled c-kit-positive CSC may reflect a parent stem cell derived from a BrdU-negative grandparent stem cell that incorporated the halogenated nucleotide during the first division. Subsequently, the BrdU-labeled parent stem cell entered the G0/G1 phase. Adapted from reference 25.