Table 1.
Mitotic kinases-mediated p53 phosphorylation and the possible consequences.
| Mitotic kinases | Phosphorylation sites | Outcome | References |
|---|---|---|---|
| Aurora kinases | |||
| Aurora A | Ser-215 | Inhibition of DNA binding and transcriptional activity | [85] |
| Ser-315 | Protein destabilization | [55] | |
| Aurora B | Ser-183 | Unknown | [46] |
| Ser-269/Thr284 | Inhibition of transcriptional activity | ||
| Aurora C | Unknown | ||
|
| |||
| Polo-like kinases | |||
| Plk1 | Unknown | Inhibition of transcriptional and proapoptotic activity | [146] |
| Plk2 | Unknown | ||
| Plk3 | Ser-20 | Protein stabilization | [169] |
| Plk4 | Unknown | Possibly affecting protein stabilization and transcriptional activation | [178] |
| Plk5 | Unknown | ||
|
| |||
| SAC kinases | |||
| Bub1 | Ser-37 | Possibly inducing cellular senescence | [193] |
| Mps1 | Thr-18 | p53 stabilization | [58] |
| p53-dependent postmitotic checkpoint activation | |||
| BubR1 | Unknown | p53 stabilization | [59] |