Table 1.
Human matrix metalloproteinases (MMPs).
| No. | MMP | MMP class | Enzyme | Molecular weight (kDa) | Substrates |
|---|---|---|---|---|---|
| 1 | MMP-1 | Collagenases | Collagenase-1 | 57∗
47 A |
Collagens (I, II, III, VII, and X), proteoglycans, entactin, ovostatin, MMP-2, MMP-9 |
| 2 | MMP-8 | Collagenases | Collagenase-2/neutrophil collagenase | 85∗
64 A |
Collagens (I, II, III, VII, VIII, and X), fibronectin, proteoglycans |
| 3 | MMP-13 | Collagenases | Collagenase-3 | 60∗
48 A |
Collagens (I, II, III, VII, VIII, and X), tenascin, plasminogen, aggrecan, fibronectin, osteonectin, MMP-9 |
| 4 | MMP-18 | Collagenases | Collagenase-4 | 53∗
51 A |
Type I collagen |
| 5 | MMP-2 | Gelatinases | Gelatinase-A | 72∗
66 A |
Gelatin, collagen (IV, V, VII VI, IX, and X), elastin, fibronectin |
| 6 | MMP-9 | Gelatinases | Gelatinase-A | 92∗
86 A |
Collagens (IV, V, VII, X, and XIV), gelatin, entactin, elastin, fibronectin, osteonectin, plasminogen, proteoglycans |
| 7 | MMP-3 | Stromelysins | Stromelysin-I | 60∗
52 A |
Collagens (IV, V, and IX), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen |
| 8 | MMP-10 | Stromelysins | Stromelysin-2 | 53∗
47 A |
Collagens (I, II, IV, and V), gelatin, casein, elastin, fibronectin |
| 9 | MMP-11 | Stromelysins | Stromelysin-2 | 60∗
47 A |
Collagens (IV, V, IX, and X), laminin, elastin, fibronectin, casein, proteoglycans |
| 10 | MMP-17 | Stromelysins | Homology tostromelysin-2 | 65∗
63 A |
Pro-MMP2, fibrin/fibrinogen, gelatin |
| 11 | MMP-7 | Matrisylins | Matrisylin | 28∗
19 A |
Collagen IV, gelatin, fibronectin, laminin, elastin, casein, transferrin |
| 12 | MMP-26 | Matrisylins | Matrisylin-2 | 29 | Collagen IV, fibronectin, fibrinogen, gelatin, pro-MMP9 |
| 13 | MMP-14 | MT-MMP (membrane type-MMP) | MT1-MMP | 66∗
54 A |
Collagens (I, II, III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP-2 |
| 14 | MMP-15 | MT-MMP | MT2-MMP | 76 | Fibronectin, gelatin, vitronectin, entactin, laminin, pro-MMP-2 |
| 15 | MMP-16 | MT-MMP | MT3-MMP | 65∗
63 A |
Collagen III, gelatin, casein, fibronectin, pro-MMP-2 |
| 16 | MMP-17 | MT-MMP | MT4-MMP | 65∗
63 A |
Pro-MMP-2, fibrinogen, gelatin |
| 17 | MMP-24 | MT-MMP | MT5-MMP | 73 | Fibronectin, pro-MMP-2, proteoglycans, gelatin |
| 18 | MMP-25 | MT-MMP | MT6-MMP | 62 | Pro-MMP-2, pro-MMP-9, collagen IV, gelatin, fibronectin, proteinase A |
| 19 | MMP-12 | Other enzymes | Macrophage metalloelastase | 54∗
45 A |
Collagen IV, gelatin, elastin, casein, fibronectin, vitronectin, laminin, entactin, fibrin/fibrinogen |
| 20 | MMP-19 | Other enzymes | RASI I | 59 | Collagen (I, IV) gelatin, fibronectin, laminin |
| 21 | MMP-20 | Other enzymes | Enamelysin | 56 | Amelogenin, aggrecan |
| 22 | MMP-21 | Other enzymes | 65 | ||
| 23 | MMP-22 | Other enzymes | 58∗
53 A |
||
| 24 | MMP-23 | Other enzymes | 44 | Gelatin | |
| 25 | MMP-27 | Other enzymes | 59 | ||
| 26 | MMP-28 | Other enzymes | Epilysin | 59 |
∗Zymogen molecular weight; A: active form molecular weight.