Table 2.

Correlation between MMP levels and clinicopathologic parameters. NA: not available; T: tissue; B: blood; U: urine.

Author	B/T/U	Pat/Con	Method	Expres.tm	Stage	Grade	Recurrence	Prognosis	MMP-
Gohji et al. [4]	B	146/52	Enzyme assay	Increased	NA	NA	Yes	NA	MMP-2 MMP-3
Angulo et al. [65]	B	31/11	RT-PCR	Increased	Increased	NA	NA	NA	MMP-2 MMP-9 TIMP-2
Szarvas et al. [50]	B	97/22	Enzyme assay	Increased	NA	NA	NA	Yes	MMP-7
Vasala et al. [10]	B	84/—	ELISA	Decreased	NA	NA	NA	Yes	pro-MMP-2 MMP-2 TIMP-2
Tasci et al. [67]	B	102/94	PCR lymphocytes	Increased	Increased	Increased	NA	NA	MMP-1
Offersen et al. [68]	U	188/—	Immunocapture activity assay	Increased	Increased	Increased	Yes	Yes	MMP-9
Szarvas et al. [69]	U	132/96	Enzyme assay	Increased	NA	NA	NA	Yes	MMP-7
Hoque et al. [70]	U	175	RT-PCR	Methylation	Increased	NA	NA	Yes	TIMP-3
Eissa et al. [71]	U	136/60	ELISA Gelatin zymography	Increased	NA	Increased	NA	NA	MMP-2 MMP-9 TIMP-2
Di Carlo et al. [73]	U	25/—	Gelatin zymography	Increased	Increased	Increased	NA	NA	MMP-9
Davies et al. [55]	T	42/7	In situ hybrid	Increased	Increased	NA	NA	Yes	MMP-2 MMP-9
Grignon et al. [56]	T	42/—	IHQ	Increased	Increased	NA	NA	Yes	TIMP-2
Kanayama et al. [51]	T	41/—	RT-PCR	Increased	Increased	NA	NA	Yes	MMP-2 TIMP-2
Papathoma et al. [57]	T		Gelatin zymography IHQ	NA	NA	NA	NA	Yes	MMP-2 MMP-9
Hara et al. [61]	T	51	Northern blot analysis	NA	Increased	Increased	Yes	NA	MMP-9 TIMP-2