Stochastic, CELLSIM, and CELLGROW, Donaghey, 1981–1983 [1, 2] |
Individual cell/cell group growth model |
Phase transition probabilities, proliferation-based commands on up to 90 cell groups, contact inhibition modelled |
Monolayer cell growth achieved and RT/drug therapy applied |
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Mathematical, O'Donoghue, 1997 [3] |
Modelling exponential proliferation at small tumour sizes and Gompertzian at larger sizes |
3 LQ based parameters, 2 growth related parameters and 1 radiation induced death rate parameter |
The effects of RT described in terms of cure (clonogenic cell sterilization) and/or tumour regression/regrowth |
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Stochastic, Marcu et al., 2002–2006 [4, 5] |
Modelling tumour growth and response to radiotherapy |
Cell cycle specific surviving fractions (SF2) based on LQ model. Repopulation mechanisms during RT such as cell recruitment, accelerated stem cell division, and asymmetry loss in stem division |
The effect of conventional and altered fractionation radiotherapy on cell survival evaluated. The contribution and likeliness of repopulation mechanisms assessed |