Table 5.

Phosphorylation levels of sarcomeric proteins in patients with nonischemic cardiomyopathy before and after LVAD implantation.

	Before LVAD	After LVAD	P-value*	Nonfailing
Myosin Binding Protein C	6.1 ± 1.2	6.7 ± 1.0	0.328	4.6 ± 0.6†
Troponin T	19.2 ± 3.0	18.0 ± 3.8	0.562	20.9 ± 7.0
Troponin I	12.8 ± 4.1	21.6 ± 9.4	0.030	13.2 ± 1.9
Tropomyosin	7.9 ± 2.6	8.5 ± 2.9	0.431	8.0 ± 1.9
Regulatory Myosin Light Chain	0.5 ± 0.2	0.7 ± 0.3	0.109	0.6 ± 0.2
Serine 22,23 phosphorylated Troponin I	3.7 ± 2.3	3.4 ± 1.5	0.747	2.8 ± 0.6
Serine 43 phosphorylated Troponin I	7.5 ± 2.2	5.2 ± 1.9	0.044	12.0 ± 1.0‡

Phosphorylation levels expressed in arbitrary optical density units.

^*P-value for comparison between Before LVAD and After LVAD

^†P<0.01 for comparisons of Myosin Binding Protein C between Before LVAD vs. Nonfailing and After LVAD vs. Nonfailing

^‡P<0.001 for comparisons of Serine 43 phosphorylated Troponin I between Before LVAD vs. Nonfailing and After LVAD vs. Nonfailing